Coinciding with the twenty-fifth anniversary celebration of the UOC, the following article aims to review the main transformations that the basic areas of business have undergone over the past two and a half decades. For this, we have enjoyed the participation of five female and five male professors in the studies of economy and business, who have given us some broad strokes on some of the main changes during this period and the challenges still to come. These topics are: leadership, decision-making, internationalization, digitalization, strategy, adaptation to change, ethics, corporate social responsibility, diversity, inclusion, business modal innovation, and finance.